Studies on Molecular Orientation by Spectropolarimetry

Molecular orientation studies by pulsed electron-electron double resonance experiments.

Pulsed electron-electron double resonance (PELDOR) has proven to be a valuable tool to measure the distribution of long range distances in noncrystalline macromolecules. These experiments commonly use nitroxide spin labels as paramagnetic markers that are covalently attached to the macromolecule at specific positions. Unless these spin labels are flexible in such a manner that they exhibit an a...

Molecular docking studies on xanthohumol derivatives as novel ‎anticancer agents ‎

A set of Xanthohumol derivatives were selected and molecular docking studies of these ‎compounds on thioredoxin reductase were conducted. Based on new structural patterns using in ‎silico-screening study, new potent lead compounds were designed. The results due to validated ‎docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, ‎Val44 and Gly132 are the main a...

Studies on Molecular Similarity

Spectropolarimetry of PKS 0040−005 and the Orientation of Broad Absorption Line Quasars⋆

We have used the Very Large Telescope (VLT) to obtain spectropolarimetry of the radio-loud, double-lobed broad absorption line (BAL) quasar PKS 0040−005. We find that the optical continuum of PKS 0040−005 is intrinsically polarized at 0.7% with an electric vector position angle nearly parallel to that of the large-scale radio axis. This result is naturally explained in terms of an equatorial sc...

Spectropolarimetry of Supernovae

Overwhelming evidence has accumulated in recent years that supernova explosions are intrinsically 3-dimensional phenomena with significant departures from spherical symmetry. We review the evidence derived from spectropolarimetry that has established several key results: virtually all supernovae are significantly aspherical near maxim light; core-collapse supernovae behave differently than ther...